The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep
نویسندگان
چکیده
منابع مشابه
The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep
BACKGROUND Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified cases predating the initial identification of this form of scrapie, and epidemiological studies have indicated that it does not conform to the behaviour of an infectious disease, giving rise to the hypothesis that it represents...
متن کاملExperimental transmission of atypical scrapie to sheep
BACKGROUND Active surveillance for transmissible spongiform encephalopathies in small ruminants has been an EU regulatory requirement since 2002. A number of European countries have subsequently reported cases of atypical scrapie, similar to previously published cases from Norway, which have pathological and molecular features distinct from classical scrapie. Most cases have occurred singly in ...
متن کاملSusceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources
It has long been established that the sheep Prnp genotype influences the susceptibility to scrapie, and some studies suggest that it can also determine several aspects of the disease phenotype. Other studies, however, indicate that the source of infection may also play a role in such phenotype. To address this question an experiment was set up in which either of two different natural scrapie so...
متن کاملPhenotype Shift from Atypical Scrapie to CH1641 following Experimental Transmission in Sheep
The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease. In contrast to classical scrapie, the pathology in naturally-occurring cases of atypical scrapie appears more consistent, regardless of genotype, and is preserved on transmission within sheep homologous for th...
متن کاملExperimental Oral Transmission of Atypical Scrapie to Sheep
To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals' peripheral tissues, we challenged neonatal lambs orally with atypical scrapie; they were then killed at 12 or 24 months. Screening test results were negative for disease-specific prion protein in all but 2 recipients; they had positive results for examin...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2010
ISSN: 1746-6148
DOI: 10.1186/1746-6148-6-14